Article
A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Pearson L, Garcia J, Wu F, Modesti N, Nelson J, Gaynor R
Abstract excerpt
Regulation of human immunodeficiency virus (HIV) gene expression is dependent on specific regulatory regions in the long terminal repeat. These regions include the enhancer, SP1, "TATA," and trans-activating (TAR) regions. In addition, viral regulatory proteins such as tat and rev are important in regulating HIV gene expression. The mechanism of tat activation remains the subject of investigation, but effects at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.