Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potent inhibition of HIV-1 replication by a Tat mutant.

PloS one - 10 Nov 2009

Meredith Luke W, Sivakumaran Haran, Major Lee, Suhrbier Andreas, Harrich David

Abstract excerpt

Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-exon Tat mutants, Nullbasic exhibited transdominant negative effects on Tat-dependent transactivation. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescent Antibody Technique, Indirect
Share to Gene Products, tat
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to HeLa Cells

Share to Virion

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19901984
DOI: 10.1371/journal.pone.0007769
PMCID: PMC2768900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potent inhibition of HIV-1 replication by a Tat mutant.PMID 19901984Read ↗

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Semantic proximity Read ↗

A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.Semantic proximity Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat ProteinSemantic proximity Read ↗

Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.Semantic proximity Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.Semantic proximity Read ↗

Tat is a multifunctional viral protein that modulates cellular gene expression and functionsSemantic proximity Read ↗

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.Semantic proximity Read ↗

Functions of Tat: the versatile protein of human immunodeficiency virus type 1Semantic proximity Read ↗

Tits and bits of HIV Tat protein.Semantic proximity Read ↗

HIV-1 Tat: An update on transcriptional and non-transcriptional functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.