A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.

Abstract excerpt

BACKGROUND: Nullbasic is a mutant HIV-1 Tat protein that inhibits HIV-1 replication via three independent mechanisms that disrupts 1) reverse transcription of the viral RNA genome into a DNA copy, 2) HIV-1 Rev protein function required for viral mRNA transport from the nucleus to the cytoplasm and 3) HIV-1 mRNA transcription by RNA Polymerase II. The Nullbasic protein is derived from the subtype B strain...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antiviral Agents
• Share to CD4-Positive T-Lymphocytes