Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.

Journal of virology - 1 Mar 1999

Ulich C, Dunne A, Parry E, Hooker C W, Gaynor R B, Harrich D

Abstract excerpt

Tat expression is required for efficient human immunodeficiency virus type 1 (HIV-1) reverse transcription. In the present study, we generated a series of 293 cell lines that contained a provirus with a tat gene deletion (Deltatat). Cell lines that contained Deltatat and stably transfected vector...

Topics

Amino Acid Sequence
Cyclin-Dependent Kinases
Gene Products, tat
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Protein Serine-Threonine Kinases
RNA, Viral
Structure-Activity Relationship
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Virion

tat Gene Products, Human Immunodeficiency Virus

Cyclin-Dependent Kinase-Activating Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 9971835
DOI: 10.1128/JVI.73.3.2499-2508.1999
PMCID: PMC104497

Genes

CDK7
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9971835-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.PMID 9971835Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

Regulation of cellular gene expression and function by the human immunodeficiency virus type 1 tat proteinSemantic proximity Read ↗

Tat is a multifunctional viral protein that modulates cellular gene expression and functionsSemantic proximity Read ↗

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Semantic proximity Read ↗

Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication.Semantic proximity Read ↗

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.Semantic proximity Read ↗

Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins.Semantic proximity Read ↗

Functions of Tat: the versatile protein of human immunodeficiency virus type 1Semantic proximity Read ↗

Potent inhibition of HIV-1 replication by a Tat mutant.Semantic proximity Read ↗

HIV-1 Tat: An update on transcriptional and non-transcriptional functionsSemantic proximity Read ↗

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.