Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.

Journal of acquired immune deficiency syndromes - 1 Jul 1994

Echetebu C O, Rhim H, Herrmann C H, Rice A P

Abstract excerpt

The human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) Tat proteins Tat-1 and Tat-2 stimulate transcription of the viral long terminal repeat (LTR) sequences and are required for efficient viral replication. A class of mutant Tat proteins, termed "transdominant mutants," has been described that possesses relatively low transactivation activity, yet is able to inhibit the function of wild-type Tat. These...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Phenotype

Share to Repetitive Sequences, Nucleic Acid

Share to RNA, Viral

Share to Transfection

Source

Identifiers

PMID: 8207644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.PMID 8207644Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation.Semantic proximity Read ↗

Potent inhibition of HIV-1 replication by a Tat mutant.Semantic proximity Read ↗

Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins.Semantic proximity Read ↗

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Semantic proximity Read ↗

Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region.Semantic proximity Read ↗

HIV Tat protein requirements for transactivation and repression of transcription are separable.Semantic proximity Read ↗

Purification and functional characterization of wild-type and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli.Semantic proximity Read ↗

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.Semantic proximity Read ↗

Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.Semantic proximity Read ↗

Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.