Article
Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.
Journal of acquired immune deficiency syndromes - 1 Jul 1994
Echetebu C O, Rhim H, Herrmann C H, Rice A P
Abstract excerpt
The human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) Tat proteins Tat-1 and Tat-2 stimulate transcription of the viral long terminal repeat (LTR) sequences and are required for efficient viral replication. A class of mutant Tat proteins, termed "transdominant mutants," has been descri...
Topics
- Amino Acid Sequence
- Arginine
- Cell Line
- Gene Expression Regulation, Viral
- Gene Products, tat
- Genes, tat
- HIV-2
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype