Article
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins.
Gene therapy - 1 Jul 1998
Fraisier C, Abraham D A, van Oijen M, Cunliffe V, Irvine A, Craig R, Dzierzak E A
Abstract excerpt
Strategies to inhibit the spread of HIV infection consist of a number of specific molecular approaches. Since viral production is dependent upon Tat-mediated transactivation of the HIV promoter through the Tat activating region (TAR), tat antisense RNA, anti-tat ribozymes, TAR decoys and dominant negative Tat mutant proteins have been suggested as therapeutic inhibitors. We produced and tested several Tat mutant...
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