Article
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins.
Gene therapy - 1 Jul 1998
Fraisier C, Abraham D A, van Oijen M, Cunliffe V, Irvine A, Craig R, Dzierzak E A
Abstract excerpt
Strategies to inhibit the spread of HIV infection consist of a number of specific molecular approaches. Since viral production is dependent upon Tat-mediated transactivation of the HIV promoter through the Tat activating region (TAR), tat antisense RNA, anti-tat ribozymes, TAR decoys and dominant...
Topics
- Cell Line
- Dose-Response Relationship, Drug
- Drosophila Proteins
- Gene Products, tat
- Genetic Therapy
- HIV Infections
- HIV Long Terminal Repeat
- HIV-1
- Homeodomain Proteins
- Humans
- Mutation
- Recombinant Fusion Proteins
- T-Lymphocytes
- Transcription Factors
- Transcriptional Activation
- Virus Replication
- tat Gene Products, Human Immunodeficiency Virus