Article
Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2013
Elias Sean C, Collins Katharine A, Halstead Fenella D, Choudhary Prateek, Bliss Carly M, Ewer Katie J, Sheehy Susanne H, Duncan Christopher J A, Biswas Sumi, Hill Adrian V S, Draper Simon J
Abstract excerpt
Overcoming antigenic variation is one of the major challenges in the development of an effective vaccine against Plasmodium falciparum, a causative agent of human malaria. Inclusion of multiple Ag variants in subunit vaccine candidates is one strategy that has aimed to overcome this problem for the leading blood-stage malaria vaccine targets, that is, merozoite surface protein 1 (MSP1) and apical membrane Ag 1...
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