Article
Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria.
Infection and immunity - 1 Oct 2010
Spring Michele D, Chelimo Kiprotich, Tisch Daniel J, Sumba Peter Odada, Rochford Rosemary, Long Carole A, Kazura James W, Moormann Ann M
Abstract excerpt
Cross-sectional seroepidemiological studies of populations naturally exposed to Plasmodium falciparum suggest an association between protection from malaria and circulating antibodies to the carboxyl terminus of merozoite surface protein 1 (MSP1). Questions remain regarding the significance of cell-mediated immunity to MSP1 in conferring protection and inducing immunologic memory. Vaccine constructs have been...
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