Article
Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.
BMC medicine - 16 Oct 2014
Terheggen Ulrich, Drew Damien R, Hodder Anthony N, Cross Nadia J, Mugyenyi Cleopatra K, Barry Alyssa E, Anders Robin F, Dutta Sheetij, Osier Faith H A, Elliott Salenna R, Senn Nicolas, Stanisic Danielle I, Marsh Kevin, Siba Peter M, Mueller Ivo, Richards Jack S, Beeson James G
Abstract excerpt
BACKGROUND: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to...
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