Article
Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence.
The American journal of tropical medicine and hygiene - 1 Jan 2000
Lee E A, Flanagan K L, Odhiambo K, Reece W H, Potter C, Bailey R, Marsh K, Pinder M, Hill A V, Plebanski M
Abstract excerpt
The merozoite surface protein-1 (MSP1) is the most studied malaria blood-stage vaccine candidate. Lymphokines such as interferon gamma (IFN-gamma) and interleukin 4 (IL-4) may mediate blood-stage specific protection. Here we identify Plasmodiumfalciparum MSP1 T-cell epitopes capable of rapid induction of IFN-gamma and/or IL-4 from peripheral blood mononuclear cells of East and West African donors. Both allelic...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acid Sequence
- Animals
- Case-Control Studies
- DNA Primers
- Epitopes, T-Lymphocyte
- Female
- Gambia
- Humans
- Interferon-gamma
- Interleukin-4