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Article

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.

PloS one - 1 Jan 2012

Drew Damien R, Hodder Anthony N, Wilson Danny W, Foley Michael, Mueller Ivo, Siba Peter M, Dent Arlene E, Cowman Alan F, Beeson James G

Abstract excerpt

Apical Membrane Antigen 1 (AMA1) is a leading malaria vaccine candidate and a target of naturally-acquired human immunity. Plasmodium falciparum AMA1 is polymorphic and in vaccine trials it induces strain-specific protection. This antigenic diversity is a major roadblock to development of AMA1 as a malaria vaccine and understanding how to overcome it is essential. To assess how AMA1 antigenic diversity limits...

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Identifiers

PMID: 23227229
DOI: 10.1371/journal.pone.0051023
PMCID: PMC3515520

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Source receipt: pubmed, retrieved 7 Sept 2026.

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