Article
Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.
The Journal of infectious diseases - 1 Feb 2013
Ouattara Amed, Takala-Harrison Shannon, Thera Mahamadou A, Coulibaly Drissa, Niangaly Amadou, Saye Renion, Tolo Youssouf, Dutta Sheetij, Heppner D Gray, Soisson Lorraine, Diggs Carter L, Vekemans Johan, Cohen Joe, Blackwelder William C, Dube Tina, Laurens Matthew B, Doumbo Ogobara K, Plowe Christopher V
Abstract excerpt
The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, had allele-specific efficacy against clinical malaria in a phase II trial in Malian...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.