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Article

Structural basis of antigenic escape of a malaria vaccine candidate

16 Jul 2007

Abstract excerpt

Antibodies against the malaria vaccine candidate apical membrane antigen-1 (AMA-1) can inhibit invasion of merozoites into RBC, but antigenic diversity can compromise vaccine efficacy. We hypothesize that polymorphic sites located within inhibitory epitopes function as antigenic escape residues (AER). By using an in vitro model of antigenic escape, the inhibitory contribution of 24 polymorphic sites of the 3D7...

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PMID: 17636123
DOI: 10.1073/pnas.0701464104

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