Article
Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.
Infection and immunity - 1 Nov 2014
Harris Karen S, Adda Christopher G, Khore Madhavi, Drew Damien R, Valentini-Gatt Antonina, Fowkes Freya J I, Beeson James G, Dutta Sheetij, Anders Robin F, Foley Michael
Abstract excerpt
Apical membrane antigen 1 (AMA1) is a leading malarial vaccine candidate; however, its polymorphic nature may limit its success in the field. This study aimed to circumvent AMA1 diversity by dampening the antibody response to the highly polymorphic loop Id, previously identified as a major target of strain-specific, invasion-inhibitory antibodies. To achieve this, five polymorphic residues within this loop were...
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