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Article

Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.

Infection and immunity - 1 Nov 2010

Osier Faith H A, Weedall Gareth D, Verra Federica, Murungi Linda, Tetteh Kevin K A, Bull Pete, Faber Bart W, Remarque Ed, Thomas Alan, Marsh Kevin, Conway David J

Abstract excerpt

Although Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate, extensive allelic diversity may compromise its vaccine potential. We have previously shown that naturally acquired antibodies to AMA1 were associated with protection from clinical malaria in this Kenyan population. To assess the impact of allelic diversity on naturally acquired immunity, we first sequenced the...

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Identifiers

PMID: 20732997
DOI: 10.1128/IAI.00576-10
PMCID: PMC2976345

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