Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine.

Malaria journal - 21 Jun 2010

Ouattara Amed, Mu Jianbing, Takala-Harrison Shannon, Saye Renion, Sagara Issaka, Dicko Alassane, Niangaly Amadou, Duan Junhui, Ellis Ruth D, Miller Louis H, Su Xin-zhuan, Plowe Christopher V, Doumbo Ogobara K

Abstract excerpt

BACKGROUND: Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1) is a leading blood stage malaria vaccine candidate with extreme diversity, potentially limiting its efficacy against infection and d...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Protozoan
Share to Double-Blind Method
Share to Immunization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Malaria Vaccines

Share to Membrane Proteins

Share to Plasmodium falciparum

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20565971
DOI: 10.1186/1475-2875-9-175
PMCID: PMC2908102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20565971-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine.PMID 20565971Read ↗

Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.Semantic proximity Read ↗

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.Semantic proximity Read ↗

Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.Semantic proximity Read ↗

Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine DevelopmentSemantic proximity Read ↗

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.Semantic proximity Read ↗

Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults.Semantic proximity Read ↗

Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.Semantic proximity Read ↗

Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1Semantic proximity Read ↗

Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccinationSemantic proximity Read ↗

Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.Semantic proximity Read ↗

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design.Semantic proximity Read ↗

Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.