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Article

53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.

Molecular cell - 21 Feb 2013

Jankovic Mila, Feldhahn Niklas, Oliveira Thiago Y, Silva Israel T, Kieffer-Kwon Kyong-Rim, Yamane Arito, Resch Wolfgang, Klein Isaac, Robbiani Davide F, Casellas Rafael, Nussenzweig Michel C

Abstract excerpt

Deficiencies in factors that regulate the DNA damage response enhance the incidence of malignancy by destabilizing the genome. However, the precise influence of the DNA damage response on regulation of cancer-associated rearrangements is not well defined. Here we examine the genome-wide impact of tumor protein P53-binding protein 1 (53BP1) deficiency in lymphoma and translocation. While both activation-induced...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Cytidine Deaminase

Share to Gene Rearrangement

Share to Lymphoma, B-Cell

Share to Translocation, Genetic

Share to Tumor Suppressor p53-Binding Protein 1

Source

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Identifiers

PMID: 23290917
DOI: 10.1016/j.molcel.2012.11.029
PMCID: PMC3658150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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