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Article

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.

Molecular and cellular biology - 1 Nov 2005

Ward Irene M, Difilippantonio Simone, Minn Kay, Mueller Melissa D, Molina Julian R, Yu Xiaochun, Frisk Craig S, Ried Thomas, Nussenzweig Andre, Chen Junjie

Abstract excerpt

p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both copies of 53BP1 greatly accelerates lymphomagenesis in a p53-null background, suggesting that 53BP1 and p53 cooperate in tumor suppression. A subset of 53BP1-/- p53-/- lymphomas, like those in H2AX-/- p53-/- mice,...

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Identifiers

PMID: 16260621
DOI: 10.1128/MCB.25.22.10079-10086.2005
PMCID: PMC1280262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.PMID 16260621Read ↗

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.Semantic proximity Read ↗

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Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway ChoiceSemantic proximity Read ↗

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