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Article

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

27 Apr 2017

Abstract excerpt

Abstract Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymerase 3...

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PMID: 28447610
DOI: 10.1038/ncomms15110

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