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Article

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006

Morales Julio C, Franco Sonia, Murphy Michael M, Bassing Craig H, Mills Kevin D, Adams Melissa M, Walsh Nicole C, Manis John P, Rassidakis George Z, Alt Frederick W, Carpenter Phillip B

Abstract excerpt

p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle factors including the H2AX histone variant. Mice deficient for 53BP1 (53BP1(-/-)) are sensitive to ionizing radiation and immunodeficient because of impaired Ig heavy chain class switch recombination. Here we show that, as compared with p53(-/-) mice,...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16492765
DOI: 10.1073/pnas.0511259103
PMCID: PMC1413919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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