Article

Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers

2020-02-12

Abstract excerpt

Chromosomal translocations are important drivers of haematological malignancies whereby proto-oncogenes are activated by juxtaposition with enhancers, often called enhancer hijacking . We analysed the epigenomic consequences of rearrangements between the super-enhancers of the immunoglobulin heavy locus ( IGH) and proto-oncogene CCND1 that are common in B-cell malignancies. By integrating BLUEPRINT epigenomic d...

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Literature Corpus work: 185228ff-0c8f-5777-8cc6-01b48cf87e1d
DOI: 10.1101/2020.02.12.938563

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Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancersDOI 10.1101/2020.02.12.938563Read

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