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Article

Genetic variation of fifteen folate metabolic pathway associated gene loci and the risk of incident head and neck carcinoma: the Women's Genome Health Study.

Clinica chimica acta; international journal of clinical chemistry - 15 Mar 2013

Zee Robert Y L, Rose Lynda, Chasman Daniel I, Ridker Paul M

Abstract excerpt

OBJECTIVE: Recent studies have demonstrated the importance of folate metabolic pathway (FMP) in the pathogenesis of head and neck carcinoma (HNC). Whether the genetic variation within the FMP associated genes modulates HNC remains elusive. To date, prospective, epidemiological data on the relationship of FMP gene variation with the risk of HNC are sparse. METHODS: The association between 203 tag-SNPs (tSNPs) of...

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Source

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Identifiers

PMID: 23276522
DOI: 10.1016/j.cca.2012.11.030
PMCID: PMC3582777

Genes

RFC1
DHFR
MTHFR
TYMS
BHMT
CBS
FOLR1
FOLR2
FOLR3
MTHFD1
MTR
MTRR
SHMT1
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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