Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.

doi:10.1002/cncr.29465

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Article

Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.

Cancer - 15 Oct 2015

Cheng Ting-Yuan David, Makar Karen W, Neuhouser Marian L, Miller Joshua W, Song Xiaoling, Brown Elissa C, Beresford Shirley A A, Zheng Yingye, Poole Elizabeth M, Galbraith Rachel L, Duggan David J, Habermann Nina, Bailey Lynn B, Maneval David R, Caudill Marie A, Toriola Adetunji T, Green Ralph, Ulrich Cornelia M

Abstract excerpt

BACKGROUND: Investigations of folate-mediated one-carbon metabolism (FOCM) genes and gene-nutrient interactions with respect to colorectal cancer (CRC) risk are limited to candidate polymorphisms and dietary folate. This study comprehensively investigated associations between genetic variants in FOCM and CRC risk and whether the FOCM nutrient status modified these associations. METHODS: Two hundred eighty-eight...

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Identifiers

PMID: 26108676
DOI: 10.1002/cncr.29465
PMCID: PMC4592375

Genes

MTHFD1
MTRR
TYMS
BHMT2
CBS
DHFR
DNMT1
FOLH1
MTHFR
PON1
PRDM2
TCN2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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