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Article

Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Dec 2020

De Castro Tialfi Bergamin, Rodrigues-Fleming Gabriela Helena, Oliveira-Cucolo Juliana Garcia De, Silva Jéssika Nunes Gomes Da, Silva Fabia Pigatti, Raposo Luiz Sérgio, Maniglia José Victor, Pavarino Erika Cristina, Batista Arantes Lidia Maria Rebolho, Galbiatti-Dias Ana Lívia Silva, Maria Goloni Bertollo Eny

Abstract excerpt

BACKGROUND: Folate is essential for DNA synthesis, repair, and methylation. Polymorphisms in genes associated with folate metabolism may alter these processes and, consequently, modulate cancer development. AIM: We aimed to assess DNMT3B -149C/T (rs2424913), DNMT3B -283T/C (rs6087990), DNMT3B -579G/T (rs2424909), DHFR 19-pb ins/del (rs70991108), SHMT1 1420C/T (rs1979277), and TYMS 28-bp tandem repeat ()...

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Identifiers

PMID: 33369477
DOI: 10.31557/APJCP.2020.21.12.3751
PMCID: PMC8046294

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