Article
Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia.
Epigenetics - 1 Mar 2013
Farkas Sanja A, Böttiger Anna K, Isaksson Helena S, Finnell Richard H, Ren Aiguo, Nilsson Torbjörn K
Abstract excerpt
The objectives of this study were to identify tissue-specific differentially methylated regions (T-DMR's) in the folate transport genes in placental tissue compared with leukocytes, and from placental tissues obtained from normal infants or with neural tube defects (NTDs). Using pyrosequencing, we developed methylation assays for the CpG islands (CGIs) and the CGI shore regions of the folate receptor α (FOLR1),...
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