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Article

Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2012

Galbiatti Ana Lívia Silva, da Silva Lidia Maria Rebolho Batista, Ruiz-Cintra Mariangela Torreglosa, Raposo Luis Sérgio, Maníglia José Victor, Pavarino Erika Cristina, Goloni-Bertollo Eny Maria

Abstract excerpt

Genetic polymorphisms in folate metabolism may affect the risk of head and neck cancer (HNSCC) due to its involvement in DNA methylation and synthesis. We conducted a case-control study (265 HNSCC cases and 466 non-cancer controls) to investigate associations of MTHFR C677T and A1298C, MTR A2756G, MTRR A66G, RFC1 A80G, MTHFD1 G1958A, CBS 844ins68, TC2 C776G and A67G, SHMT C1420T and BHMT G742A polymorphisms with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22051736
DOI: 10.1016/j.ejca.2011.09.025

Genes

MTHFR
MTR
RFC1
CBS
MTHFD1
BHMT
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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