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Article

MTHFD1 G1958A, BHMT G742A, TC2 C776G and TC2 A67G polymorphisms and head and neck squamous cell carcinoma risk.

Molecular biology reports - 1 Feb 2012

da Silva Lidia Maria Rebolho Batista, Galbiatti Ana Lívia Silva, Ruiz Mariangela Torreglosa, Raposo Luiz Sérgio, Maniglia José Victor, Pavarino Erika Cristina, Goloni-Bertollo Eny Maria

Abstract excerpt

Alterations in folate metabolism may contribute to the process of carcinogenesis by influencing DNA methylation and genomic stability. Polymorphisms in genes encoding enzymes involved in this pathway may alter enzyme activity and consequently interfere in concentrations of homocysteine and S-adenosylmethionine that are important for DNA synthesis and cellular methylation reactions. The objectives were to...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21630102
DOI: 10.1007/s11033-011-0813-3

Genes

BHMT
MTHFD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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