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Article

Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.

The American journal of clinical nutrition - 1 Oct 2008

DeVos Lauren, Chanson Aurelie, Liu Zhenhua, Ciappio Eric D, Parnell Laurence D, Mason Joel B, Tucker Katherine L, Crott Jimmy W

Abstract excerpt

BACKGROUND: Folate is an essential nutrient that supports nucleotide synthesis and biological methylation reactions. Diminished folate status results in chromosome breakage and is associated with several diseases, including colorectal cancer. Folate status is also inversely related to plasma homocysteine concentrations -- a risk factor for cardiovascular disease. OBJECTIVE: We sought to gain further understanding...

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Topics

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Share to Chromosome Aberrations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Gene Expression Regulation, Enzymologic

Share to Homocysteine

Share to Membrane Transport Proteins

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Uracil

Source

Open in PubMed Open full text

Identifiers

PMID: 18842806
DOI: 10.1093/ajcn/88.4.1149
PMCID: PMC2728423

Genes

MTHFR
GGH
FOLH1
RFC1
FPGS
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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