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Article

Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease.

PloS one - 1 Jan 2012

Chen Yen-Ching, Yip Ping-Keung, Huang Yi-Ling, Sun Yu, Wen Li-Li, Chu Yi-Min, Chen Ta-Fu

Abstract excerpt

BACKGROUND: Toll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD risk previously and ApoE e4 status alone showed low sensitivity in identifying late-onset AD (LOAD) patients. METHODS: A total of 269 LOAD patients were...

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Identifiers

PMID: 23272070
DOI: 10.1371/journal.pone.0050771
PMCID: PMC3525588

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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