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Article

Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population.

Current Alzheimer research - 1 May 2012

Yu Jin-Tai, Miao Dan, Cui Wei-Zhen, Ou Jiang-Rong, Tian Yan, Wu Zhong-Chen, Zhang Wei, Tan Lan

Abstract excerpt

Toll-like receptor 4 (TLR4) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located within the previous identified linkage region of AD on chromosome 9q, and functionally is involved in the microglia-mediated inflammatory response, amyloid-β (Aβ) plaque formation and Aβ clearance. To test whether variants in the TLR4 gene are associated with late-onset AD...

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Source

Identifiers

PMID: 22272615
DOI: 10.2174/156720512800492495

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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