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Article

Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease.

Journal of neuroinflammation - 11 Oct 2011

Yu Jin-Tai, Mou Shan-Mao, Wang Li-Zhu, Mao Cai-Xia, Tan Lan

Abstract excerpt

BACKGROUND: Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and functionally is involved in the microglia-mediated inflammatory response and amyloid-β clearance. The -196 to -174 del polymorphism affects the TLR2 gene and alters its promoter activity. METHODS: We recruited...

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Identifiers

PMID: 21989233
DOI: 10.1186/1742-2094-8-136
PMCID: PMC3203069

Genes

TLR2

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