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Article

Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease.

Neuroscience letters - 2 Jan 2006

Minoretti Piercarlo, Gazzaruso Carmine, Vito Clara Di, Emanuele Enzo, Bianchi Marika, Coen Enrico, Reino Marta, Geroldi Diego

Abstract excerpt

Experimental data have shown an upregulated expression of toll-like receptors, particularly toll-like receptor 4 (TLR4), in neurodegeneration. The Asp299Gly polymorphism of the TLR4 gene has been associated with an attenuated receptor signalling and a blunted inflammatory response. In the present...

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Source

Identifiers

PMID: 16157451
DOI: 10.1016/j.neulet.2005.08.047

Genes

TLR4
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16157451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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