Article
No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese.
Neurobiology of aging - 1 Oct 2011
Yu Jin-Tai, Sun Yan-Ping, Ou Jiang-Rong, Cui Wei-Zhen, Zhang Wei, Tan Lan
Abstract excerpt
Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and is functionally involved in the microglia-mediated inflammatory response and amyloid β (Aβ) clearance. In the current study, 7 single nucleotide polymorphisms (SNPs) that span the TLR2 were selected and their associations...
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