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Article

Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population.

Brain research - 24 Mar 2011

Wang Li-Zhu, Yu Jin-Tai, Miao Dan, Wu Zhong-Chen, Zong Yu, Wen Cheng-Quan, Tan Lan

Abstract excerpt

The amyloid beta-protein (A-β) deposits in the brains of patients with Alzheimer's disease (AD) are closely associated with innate immune responses that were assumed to play a pivotal role in the pathogenesis of AD. Toll-like receptor 4 (TLR4) is thought to contribute to Aβ clearance. Studies hav...

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Source

Identifiers

PMID: 21236243
DOI: 10.1016/j.brainres.2011.01.007

Genes

TLR4
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21236243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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