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Article

Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer's disease in Han Chinese.

Journal of neuroinflammation - 20 Aug 2013

Wang Ying-Li, Tan Meng-Shan, Yu Jin-Tai, Zhang Wei, Hu Nan, Wang Hui-Fu, Jiang Teng, Tan Lan

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs), as major innate immune mediators, may be involved in clearance of cerebral amyloid-β (Aβ) deposits. Recently, a novel TLR9 signaling pathway has been uncovered, which is functionally associated with the immune inflammatory response and reducing Aβ burden in Alzheimer's disease (AD) mice. Therefore, TLR9 might represent a reasonable functional candidate gene for AD....

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Source

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Identifiers

PMID: 23957925
DOI: 10.1186/1742-2094-10-101
PMCID: PMC3765501

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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