Article
Mutation at amino acid position 133 of H-2Dd prevents beta 2m association and immune recognition but not surface expression.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1991
Rubocki R J, Connolly J M, Hansen T H, Melvold R W, Kim B S, Hildebrand W H, Martinko J
Abstract excerpt
The histocompatibility loss mutation H-2dm6 was derived from a mouse treated with the chemical mutagen ethylnitrosourea, and previous mapping studies implicated Dd as the affected locus. Southern blot analyses of DNA from H-2dm6 cells did not detect major deletions in the Ddm6 gene, suggesting that H-2dm6 was different from the previously characterized D region mutants H-2dm1 and H-2dm2. RNA blot analysis...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cell Membrane
- Cytotoxicity, Immunologic
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data