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Article

A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.

Immunogenetics - 1 Jan 1991

Moots R J, Matsui M, Pazmany L, McMichael A J, Frelinger J A

Abstract excerpt

In order to investigate the regions of HLA-A2 that control peptide-specific cytotoxic T lymphocyte (CTL) recognition, 37 HLA-A2 genes coding for 50 point mutations that span the alpha 2 helix were synthesized by the technique of saturation mutagenesis. Twenty-nine of these genes, which code for 41 point mutations, were transfected into C1R cells and used as targets in cytotoxicity assays, in the presence of...

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Identifiers

PMID: 1894308
DOI: 10.1007/BF00205816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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