Article
The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
Clinical pharmacology and therapeutics - 1 Feb 2013
Stocker S L, Morrissey K M, Yee S W, Castro R A, Xu L, Dahlin A, Ramirez A H, Roden D M, Wilke R A, McCarty C A, Davis R L, Brett C M, Giacomini K M
Abstract excerpt
Interindividual variation in response to metformin, first-line therapy for type 2 diabetes, is substantial. Given that transporters are determinants of metformin pharmacokinetics, we examined the effects of promoter variants in both multidrug and toxin extrusion protein 1 (MATE1) (g.-66T → C, rs2252281) and MATE2 (g.-130G → A, rs12943590) on variation in metformin disposition and response. The pharmacokinetics...
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