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Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

Pharmacogenetics and genomics - 1 Feb 2010

Toyama Kana, Yonezawa Atsushi, Tsuda Masahiro, Masuda Satohiro, Yano Ikuko, Terada Tomohiro, Osawa Riyo, Katsura Toshiya, Hosokawa Masaya, Fujimoto Shimpei, Inagaki Nobuya, Inui Ken-Ichi

Abstract excerpt

Multidrug and toxin extrusions (MATE1/SLC47A1 and MATE2-K/SLC47A2) play important roles in the renal excretion of metformin. We have previously identified the nonsynonymous MATE variants with functional defects at low allelic frequencies. The purpose of this study was to evaluate the effects of heterozygous MATE variants on the disposition of metformin in mice and humans. Pharmacokinetic parameters of metformin...

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PMID: 20016398
DOI: 10.1097/FPC.0b013e328335639f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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