The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate.

doi:10.1016/j.biopha.2021.112009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2021

Morales-Rivera Monserrat I, Alemón-Medina Radamés, Martínez-Hernández Angélica, Gómez-Garduño Josefina, Mirzaeicheshmeh Elaheh, Altamirano-Bustamante Nelly F, Ilizaliturri-Flores Ian, Mendoza-Caamal Elvia C, Pérez-Guillé María G, García-Álvarez Raquel, Contreras-Cubas Cecilia, Centeno-Cruz Federico, Revilla-Monsalve Cristina, García-Ortiz Humberto, Barajas-Olmos Francisco, Orozco Lorena

Abstract excerpt

Genetic factors that affect variability in metformin response have been poorly studied in the Latin American population, despite its being the initial drug therapy for type 2 diabetes, one of the most prevalent diseases in that region. Metformin pharmacokinetics is carried out by members of the membrane transporters superfamily (SLCs), being the multidrug and toxin extrusion protein 1 (MATE1), one of the most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypoglycemic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indians, North American

Share to Lactic Acid

Share to Metformin

Share to Mexico

Share to Molecular Dynamics Simulation

Share to Organic Cation Transport Proteins

Share to Pharmacogenetics

Source

Open in PubMed

Identifiers

PMID: 34388523
DOI: 10.1016/j.biopha.2021.112009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate.PMID 34388523Read ↗

Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.Semantic proximity Read ↗

A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.Semantic proximity Read ↗

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.Semantic proximity Read ↗

Exome Sequence Data of Eight SLC Transporters Reveal That SLC22A1 and SLC22A3 Variants Alter Metformin Pharmacokinetics and Glycemic ControlSemantic proximity Read ↗

Pharmacogenetic variation and metformin response.Semantic proximity Read ↗

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics.Semantic proximity Read ↗

A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 DiabetesSemantic proximity Read ↗

Influence of GLUT2 rs8192675, MATE1 rs2289669, and OCT2 rs316019 Genetic Polymorphism on Metformin Efficacy and Glycemic Control in Type 2 Diabetes Mellitus PatientsSemantic proximity Read ↗

An Update on the Pharmacogenomics of Metformin: Progress, Problems and PotentialSemantic proximity Read ↗

Effects of genetic variants of organic cation transporters on metformin response in newly diagnosed patients with type 2 diabetes.Semantic proximity Read ↗

Current understanding of the pharmacogenomics of metformin.Semantic proximity Read ↗

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.