Article
Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.
Pharmacogenetics and genomics - 1 Jan 2010
Becker Matthijs L, Visser Loes E, van Schaik Ron H N, Hofman Albert, Uitterlinden André G, Stricker Bruno H Ch
Abstract excerpt
OBJECTIVE: Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose lowering by metformin. In this study, we assessed whether...
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