Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.

doi:10.1097/FPC.0b013e328333bb11

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Article

Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.

Pharmacogenetics and genomics - 1 Jan 2010

Becker Matthijs L, Visser Loes E, van Schaik Ron H N, Hofman Albert, Uitterlinden André G, Stricker Bruno H Ch

Abstract excerpt

OBJECTIVE: Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene,...

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Identifiers

PMID: 19898263
DOI: 10.1097/FPC.0b013e328333bb11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19898263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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