Article
Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
Pharmacogenetics and genomics - 1 Oct 2009
Ha Choi Ji, Wah Yee Sook, Kim Mee J, Nguyen Loan, Ho Lee Jeong, Kang Ji-One, Hesselson Stephanie, Castro Richard A, Stryke Doug, Johns Susan J, Kwok Pui-Yan, Ferrin Thomas E, Goo Lee Min, Black Brain L, Ahituv Nadav, Giacomini Kathleen M
Abstract excerpt
OBJECTIVES: Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs. In this study, we characterized the transcriptional effects of five polymorphic varia...
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