Article
A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
Clinical pharmacology and therapeutics - 1 Nov 2011
Choi J H, Yee S W, Ramirez A H, Morrissey K M, Jang G H, Joski P J, Mefford J A, Hesselson S E, Schlessinger A, Jenkins G, Castro R A, Johns S J, Stryke D, Sali A, Ferrin T E, Witte J S, Kwok P-Y, Roden D M, Wilke R A, McCarty C A, Davis R L, Giacomini K M
Abstract excerpt
Multidrug and toxin extrusion 2 (MATE2-K (SLC47A2)), a polyspecific organic cation exporter, facilitates the renal elimination of the antidiabetes drug metformin. In this study, we characterized genetic variants of MATE2-K, determined their association with metformin response, and elucidated their impact by means of a comparative protein structure model. Four nonsynonymous variants and four variants in the...
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