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Identification and functional characterization of novel MATE1 genetic variations in Koreans.

Biochemical and biophysical research communications - 3 May 2013

Kim Tae Hee, Kim Kyoung Hee, Park Hyo Jin, Kim Siyoon, Choi Ji Ha

Abstract excerpt

Multidrug and toxin extrusion 1 (MATE1, SLC47A1), an organic cation transporter, plays an important role in the renal and biliary elimination of various clinical drugs, including the anti-diabetic drug metformin. The goal of this study was to identify and characterize novel genetic variants of MATE1. Five variants in the promoter region and two nonsynonymous variants, p.D64G and p.L125F, were identified in 48 DNA...

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PMID: 23558289
DOI: 10.1016/j.bbrc.2013.03.072

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