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Article

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics.

Pharmacogenetics and genomics - 1 Jul 2013

Chung Jae-Yong, Cho Sung Kweon, Kim Tae Hee, Kim Kyoung Hee, Jang Geun Hye, Kim Choon Ok, Park Eun-Mi, Cho Joo-Youn, Jang In-Jin, Choi Ji Ha

Abstract excerpt

OBJECTIVE: Human multidrug and toxin extrusion member 2 (MATE2-K, SLC47A2) plays an important role in the renal elimination of various clinical drugs including the antidiabetic drug metformin. The goal of this study was to characterize genetic variants of MATE2-K and determine their association with the pharmacokinetics of metformin. METHODS: We screened DNA samples from 48 healthy Koreans for variants in the...

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PMID: 23652408
DOI: 10.1097/FPC.0b013e3283622037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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