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Article

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.

Drug metabolism reviews - 1 Nov 2011

Damme Katja, Nies Anne T, Schaeffeler Elke, Schwab Matthias

Abstract excerpt

Multidrug and toxin extrusion proteins (MATEs; SLC47A) are mammalian transporters being predominately expressed in the brush-border membrane of proximal tubule epithelial cells in the kidney and the canalicular membrane of hepatocytes. Functionally, MATEs act as efflux transporters for organic compounds, thereby mediating the elimination process. Two isoforms, MATE1 and 2, have been identified, and, so far, only...

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Identifiers

PMID: 21923552
DOI: 10.3109/03602532.2011.602687

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