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Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis

25 Aug 2017

Abstract excerpt

Increased adipocyte lipolysis links obesity to insulin resistance. The lipid droplet coating-protein Perilipin participates in regulation of lipolysis and is implicated in obesity. In the present study we investigate epigenetic regulation of the PLIN1 gene by correlating PLIN1 CpG methylation to gene expression and lipolysis, and functionally evaluating PLIN1 promoter methylation. PLIN1 CpG methylation in...

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PMID: 28860604
DOI: 10.1038/s41598-017-09232-y

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