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Article

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations.

Journal of lipid research - 1 Dec 2017

Pelosi Michele, Testet Eric, Le Lay Soazig, Dugail Isabelle, Tang Xiaoyun, Mabilleau Guillaume, Hamel Yamina, Madrange Marine, Blanc Thomas, Odent Thierry, McMullen Todd P W, Alfò Marco, Brindley David N, de Lonlay Pascale

Abstract excerpt

Lipin-1 is a Mg2+-dependent phosphatidic acid phosphatase (PAP) that in mice is necessary for normal glycerolipid biosynthesis, controlling adipocyte metabolism, and adipogenic differentiation. Mice carrying inactivating mutations in the Lpin1 gene display the characteristic features of human familial lipodystrophy. Very little is known about the roles of lipin-1 in human adipocyte physiology. Apparently, fat...

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Topics

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Share to Adipocytes
Share to Adipose Tissue, White

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Fat Distribution

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Phosphatidate Phosphatase

Share to PPAR gamma

Share to Rhabdomyolysis

Share to Sterol Regulatory Element Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28986436
DOI: 10.1194/jlr.P075440
PMCID: PMC5711497

Genes

LPIN1
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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