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Article

ATM suppresses SATB1-induced malignant progression in breast epithelial cells.

PloS one - 1 Jan 2012

Ordinario Ellen, Han Hye-Jung, Furuta Saori, Heiser Laura M, Jakkula Lakshmi R, Rodier Francis, Spellman Paul T, Campisi Judith, Gray Joe W, Bissell Mina J, Kohwi Yoshinori, Kohwi-Shigematsu Terumi

Abstract excerpt

SATB1 drives metastasis when expressed in breast tumor cells by radically reprogramming gene expression. Here, we show that SATB1 also has an oncogenic activity to transform certain non-malignant breast epithelial cell lines. We studied the non-malignant MCF10A cell line, which is used widely in the literature. We obtained aliquots from two different sources (here we refer to them as MCF10A-1 and MCF10A-2), but...

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Source

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Identifiers

PMID: 23251624
DOI: 10.1371/journal.pone.0051786
PMCID: PMC3519734

Genes

SATB1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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