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Article

c-FOS drives reversible basal to squamous cell carcinoma transition

1 Oct 2021

Abstract excerpt

While squamous transdifferentiation within subpopulations of adenocarcinomas represents an important drug resistance problem, its underlying mechanism remains poorly understood. Here, using surface markers of resistant basal cell carcinomas (BCCs) and patient single-cell and bulk transcriptomic data, we uncover the dynamic roadmap of basal to squamous cell carcinoma transition (BST). Experimentally induced BST...

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PMID: 34610301
DOI: 10.1016/j.celrep.2021.109774

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